Virus Outbreak Malaria Drug
In a nationwide study of 368 patients in U.S. veterans hospitals, 28% who received hydroxychloroquine and usual care died, versus 11% of those getting only routine care.
A malaria drug widely touted by President Donald Trump for treating the new coronavirus showed no benefit in a large analysis of its use in U.S. veterans hospitals. There were more deaths among those given hydroxychloroquine versus standard care, researchers reported.
The nationwide study was not a rigorous experiment. But with 368 patients, it’s the largest look so far of hydroxychloroquine with or without the antibiotic azithromycin for COVID-19, which has killed more than 171,000 people as of Tuesday.
The study was posted on an online site for researchers and has has not been reviewed by other scientists. Grants from the National Institutes of Health and the University of Virginia paid for the work.
Researchers analyzed medical records of 368 male veterans hospitalized with confirmed coronavirus infection at Veterans Health Administration medical centers who died or were discharged by April 11.
About 28% who were given hydroxychloroquine plus usual care died, versus 11% of those getting routine care alone. About 22% of those getting the drug plus azithromycin died too, but the difference between that group and usual care was not considered large enough to rule out other factors that could have affected survival.
Hydroxychloroquine made no difference in the need for a breathing machine, either.
Researchers did not track side effects, but noted a hint that hydroxychloroquine might have damaged other organs. The drug has long been known to have potentially serious side effects, including altering the heartbeat in a way that could lead to sudden death.
Earlier this month, scientists in Brazil stopped part of a study testing chloroquine, an older drug similar to hydroxychloroquine, after heart rhythm problems developed in one-quarter of people given the higher of two doses being tested.
RELATED: Trump Won’t Stop Promoting Controversial Malaria Drug That Has Dangerous Side Effects
Many doctors have been leery of the drug.
At the University of Wisconsin, Madison, “I think we’re all rather underwhelmed” at what’s been seen among the few patients there who’ve tried it, said Dr. Nasia Safdar, medical director of infection control and prevention.
Patients asked about it soon after Trump started promoting its use, “but now I think that people have realized we don’t know if it works or not” and needs more study, said Safdar, who had no role in the VA analysis.
The NIH and others have more rigorous tests underway.
Politics
VIDEO: Youngkin won’t add legal protection for birth control access
Access to birth control remains vulnerable to potential future attacks after Republican Gov. Glenn Youngkin effectively blocked a bill that would...
Trump says he would allow red states to track pregnancies, prosecute abortion ban violators
In an interview published by Time magazine this week, former president Donald Trump detailed his plans for a potential second term and said he would...
Local News
The zodiac signs of 12 iconic women offer insight into their historic accomplishments
Zodiac signs can tell you a lot about someone’s personality. Whether they’re an earth, water, air, or fire sign, these 12 categories (which are...
Virginia verses: Celebrating 5 poetic icons for National Poetry Month
There’s no shortage of great writers when it comes to our commonwealth. From the haunting verses of Edgar Allan Poe, who found solace in Richmond's...